Not all the air we breathe in is able to be used for the exchange of oxygen and carbon dioxide. In adults, it is usually in the range of 150 mL. In physiology, dead space is air that is inhaled by the body in breathing, but does not partake in gas exchange. Risk calculators and risk factors for Dead spaceĮditor-In-Chief: C. US National Guidelines Clearinghouse on Dead spaceĭirections to Hospitals Treating Dead space Ongoing Trials on Dead space at Clinical Articles on Dead space in N Eng J Med, Lancet, BMJ Over the past two decades, there has been increasing interest in dead space since the publication by Nuckton et al. Dead space ventilation-related indices remain hampered by several deflects notwithstanding, for this catastrophic syndrome, they may facilitate better stratifications and identifications of subphenotypes, thereby providing therapy tailored to individual needs.Ī hallmark of classical ARDS is an increased shunt caused by alveolar collapse and/or alveolar flooding from a physiological viewpoint. These parameters have already been applied to positive end expiratory pressure titration, prediction of responses to the prone position and the field of extracorporeal life support for patients suffering from ARDS. Thus, new attention has been given to this group of dead space ventilation-related indices, such as physiological dead space fraction, ventilatory ratio, and end-tidal-to-arterial PCO 2 ratio, which, albeit distinctive, are all global indices with which to assess the relationship between ventilation and perfusion. Cumulative evidence has demonstrated that the ventilatory ratio closely correlates with mortality in acute respiratory distress syndrome (ARDS), and a primary feature in coronavirus disease 2019 (COVID-19)-ARDS is increased dead space that has been reported recently.
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